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The research centre uses a multidisciplinary translational approach with the overall aim to improve the prevention, diagnosis and treatment of osteoporosis and rheumatoid arthritis, two of the most common diseases in Sweden.

Osteoporosis and rheumatoid arthritis are common diseases in Sweden. The highest incidence of osteoporosis-related fractures in the world is found in Sweden and Norway. The genetic and environmental factors underlying this high fracture risk in Sweden are unknown.

Estrogen is an important regulator of both bone metabolism and immune functions and it has been proposed that the immune system is involved in the effects of estrogen on bone. Combined knowledge about the estrogenic effects on bone and immune functions can therefore facilitate the development of new treatment strategies for bone loss in osteoporosis and rheumatoid arthritis. Long-term exposure to estrogen has certain side effects in humans and compounds, with beneficial effects on bone and immune system without adverse effects on reproductive tissues would be desirable.

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Sidansvarig: Marie Lagerquist|Sidan uppdaterades: 2010-06-23

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